This is a fascinating summary of research done on the Allium family (onions, shallots, garlic) and their benefit on inflammation, reduction of spike protein, and reduction of cancer risk.
What dose of Quercetin do you recommend? I am currently taking 800MG 1X per day. I have a feeling that is not enough. I take 5000 IU D3 with 200Mcg K2 in the cold months. Also 50Mg Zinc.
TO INCREASE ABSORPTION of quercetin and hard to absorb "herbs". "In Ayurvedic medicine you take remedies together with ghee and honey - fat and sugar." (Elizabeth)
From some reading I am thinking that some? basic simple process of coating with a sugar and then a fat? or a fat then a sugar? or all at once? would substantially increase absorption of many harder to absorb herbs and the like.
"While searching to find how to increase absorption of quercetin I found two patents. The first is an Indena SpA patent concerning "Quercefit"- "Quercetin Phytosome" In their earlier application documents ( only the final 2020 patent seems easily available now) they made an interesting revelation that a simple mechanical mixture of quercetin and maltodextrin or fructose (or other sugar) and lecithin (they use sunflower) in the range of 1-1-1 or any number of ratios increased absorption by 10 times while their lysosomal/phytosome product where they dissolve all in 190 proof ethanol which, at that time, they said increased absorption by 20 times. Now in the final document they claim that that their full process increases absorption by 50 times and they make no mention of the efficacy of the simple mechanical mixture but they do put a graph at the very beginning of the document which shows the low absorption of quercetin, the higher absorption of the :"physical mixture" (mechanical mixture) and the highest absorption of their "solid dispersion" which is their alcohol dissolved and dried "phytosome product Quercefit. That graph is best seen in the pdf US20200.... They say the use of the "sugar" is important.
A mortar and pestle is the obvious choice.I first used the back of a tablespoon against a plate to grind together the quercetin and the maltodextrin (sugar) then the lecithin.
I have since dissolved the "sugar" (nutricost organic maltodextrin "TapiOK" brand) in a bit of water then mixed in the harder to absorb "herb" then mixed in the Now brand sunflower lecithin then added olive oil. I wonder would it be better to dry the maltodextrin herb lecithin mix then add olive oil? Dissolving the maltodextrin does seem more effective way to "attach" the "sugar", and lecithin does attach to both water and fat and may, then, help present to a fat receptive absorption site in the body as does the maltodextrin absorb easily into the body as per its use by elite long distance runners (some like straight maltodextrin and some like 3 parts maltodextrin and 1 part fructose in water +++ for fuel and hydration during the run)
"Additional and related Surprising observations include that a combination of quercetin, vitamin B3. and vitamin C maintains quercetin levels in plasma up to five times those of quercetin alone or a combination of quercetin..." " In one aspect, the invention features a composition containing quercetin, vitamin B3, and vitamin C, in which a weight ratio between quercetin, vitamin B3, and vitamin C is 1:0.02-1:0.2-2.5.
Fascinating back info. Do you opine that the commercially produced supplement combos are untrustworthy (in general?). I was hoping that unlike the AMA and FDA, the USP label was a GOOD thing, not captured by BigHarma.
I've been taking a supp composed of NAC w/D3K2 Zinc Quercetin & Sarracenia for a year.
Despite "our" problems, I prefer products made in USA, based on quality control best practices regs for supplements and our litigious population.
Maybe I've been naive, but I have hopes that non-FDA-approved stuff is safer, in light of conflict of interest exposé substack articles.
You wrote "Do you opine that the commercially produced supplement combos are untrustworthy (in general?)" No and I do not know. Not knowing is the problem.
No doubt that some are untrustworthy and some are way overpriced. It is quite a task to try and figure out "best practice" from the vast resource of information available.
there is a study showing, via measuring blood levels for Quercetin, that there is a short ~8 hour window of bioavailability after ingestion. This would suggest taking whatever daily amount is desired divided into perhaps three doses. , particularly in such as the circumstance of early treatment for covid where Quercetin is relied upon to also aid zinc entry into the infected cell and the best practice of 1 or 2 pills worth of Hydroxychloroquine taken via nebulization is not available.
also for background "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans"
I sense that slow, low temp, cooking your onions in a good amount of olive oil (or other good oil) then adding in the garlic for a short cook in the oil is a good "soup starter" practice.
Allium are pretty and EASY to grow. Chives and ramps (hard to find and picky to grow) are in that family also.
What dose of Quercetin do you recommend? I am currently taking 800MG 1X per day. I have a feeling that is not enough. I take 5000 IU D3 with 200Mcg K2 in the cold months. Also 50Mg Zinc.
TO INCREASE ABSORPTION of quercetin and hard to absorb "herbs". "In Ayurvedic medicine you take remedies together with ghee and honey - fat and sugar." (Elizabeth)
From some reading I am thinking that some? basic simple process of coating with a sugar and then a fat? or a fat then a sugar? or all at once? would substantially increase absorption of many harder to absorb herbs and the like.
"While searching to find how to increase absorption of quercetin I found two patents. The first is an Indena SpA patent concerning "Quercefit"- "Quercetin Phytosome" In their earlier application documents ( only the final 2020 patent seems easily available now) they made an interesting revelation that a simple mechanical mixture of quercetin and maltodextrin or fructose (or other sugar) and lecithin (they use sunflower) in the range of 1-1-1 or any number of ratios increased absorption by 10 times while their lysosomal/phytosome product where they dissolve all in 190 proof ethanol which, at that time, they said increased absorption by 20 times. Now in the final document they claim that that their full process increases absorption by 50 times and they make no mention of the efficacy of the simple mechanical mixture but they do put a graph at the very beginning of the document which shows the low absorption of quercetin, the higher absorption of the :"physical mixture" (mechanical mixture) and the highest absorption of their "solid dispersion" which is their alcohol dissolved and dried "phytosome product Quercefit. That graph is best seen in the pdf US20200.... They say the use of the "sugar" is important.
A mortar and pestle is the obvious choice.I first used the back of a tablespoon against a plate to grind together the quercetin and the maltodextrin (sugar) then the lecithin.
I have since dissolved the "sugar" (nutricost organic maltodextrin "TapiOK" brand) in a bit of water then mixed in the harder to absorb "herb" then mixed in the Now brand sunflower lecithin then added olive oil. I wonder would it be better to dry the maltodextrin herb lecithin mix then add olive oil? Dissolving the maltodextrin does seem more effective way to "attach" the "sugar", and lecithin does attach to both water and fat and may, then, help present to a fat receptive absorption site in the body as does the maltodextrin absorb easily into the body as per its use by elite long distance runners (some like straight maltodextrin and some like 3 parts maltodextrin and 1 part fructose in water +++ for fuel and hydration during the run)
the other patent US8440... helps inform the usefulness of taking quercetin with B3 and C. https://patents.google.com/patent/US8440704B2/en
"Additional and related Surprising observations include that a combination of quercetin, vitamin B3. and vitamin C maintains quercetin levels in plasma up to five times those of quercetin alone or a combination of quercetin..." " In one aspect, the invention features a composition containing quercetin, vitamin B3, and vitamin C, in which a weight ratio between quercetin, vitamin B3, and vitamin C is 1:0.02-1:0.2-2.5.
https://patents.google.com/patent/US20200206186A1/en?oq=US20200206186A1
https://patentimages.storage.googleapis.com/ab/aa/e9/41f67fcf738609/US20200206186A1.pdf
Fascinating back info. Do you opine that the commercially produced supplement combos are untrustworthy (in general?). I was hoping that unlike the AMA and FDA, the USP label was a GOOD thing, not captured by BigHarma.
I've been taking a supp composed of NAC w/D3K2 Zinc Quercetin & Sarracenia for a year.
Despite "our" problems, I prefer products made in USA, based on quality control best practices regs for supplements and our litigious population.
Maybe I've been naive, but I have hopes that non-FDA-approved stuff is safer, in light of conflict of interest exposé substack articles.
? 🤔
You wrote "Do you opine that the commercially produced supplement combos are untrustworthy (in general?)" No and I do not know. Not knowing is the problem.
No doubt that some are untrustworthy and some are way overpriced. It is quite a task to try and figure out "best practice" from the vast resource of information available.
Om Tat Sat - seek a lot - go with what you got
there is a study showing, via measuring blood levels for Quercetin, that there is a short ~8 hour window of bioavailability after ingestion. This would suggest taking whatever daily amount is desired divided into perhaps three doses. , particularly in such as the circumstance of early treatment for covid where Quercetin is relied upon to also aid zinc entry into the infected cell and the best practice of 1 or 2 pills worth of Hydroxychloroquine taken via nebulization is not available.
also for background "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans"
https://www.mdpi.com/2072-6643/11/10/2288
I sense that slow, low temp, cooking your onions in a good amount of olive oil (or other good oil) then adding in the garlic for a short cook in the oil is a good "soup starter" practice.