Part 2: The vaccinated are losing IgG3 immunity and increasing IgG4 immune responses to viruses and bacteria. And cancer fighting ability
Today’s post comes from two articles by Dr. Jessica Rose
First, we start by a caption from Alex Berenson and his substack post:
Next at bat:
Today we dig into Dr. Jessica Rose’s analysis of IgG4 illnesses. Her data comes from this journal article: https://www.science.org/doi/10.1126/sciimmunol.ade2798
“Repeated injections with modified mRNA encapsulated by LNPs messes up your immune system. It messes it up in a specific way. We have evidence from this work that the fibrosis and organ destruction we are witnessing in countless numbers of folks post COVID injection, is due to the shots and more specifically, likely due to the eventual class switching to IgG4 and subsequent prevalence (perhaps dominance) of this antibody subclass. Just so that you know, the typical relative percentages of the four subclasses of IgG in the blood are the following: 60-70% IgG1, 20-30% IgG2, 5-8% IgG3, 1-3% IgG4. Lets dig into IgG4 disease or IgG4-related disease (IgG4RD). It mainly affects middle-aged to elderly men.9 Its clinical symptoms are relatively mild, and the condition usually comes to clinical attention due to swollen organs or even organ damage. Many patients with IgG4RD respond very well to steroid therapy, but without treatment, this disease is fatal.10 A paper published in 2014 revealed death by IgG4 involvement by coronary artery occlusion by thrombosis.11
In my research, I found many papers covering IgG4RD subject matter from all around the world: it is most certainly a well-studied, albeit emerging ‘disease’. It’s more like a bunch of diseases that involve IgG4. Diseases such as Mikulicz’s disease, Sjögren’s syndrome and autoimmune pancreatitis (AIP) are all linked to IgG4.
(There is that autoimmune illness discussion again…….)
IgG4RD becomes clinically-evident due to organ swelling and can be remedied with steroid therapy. Diagnosis can be confirmed with histopathology. This disease can indeed affect a multitude of organs and has organ-specific diseases named accordingly affiliated with the pancreas, the lungs, the bile ducts, the kidneys, the meninges, the lacrimal (tear) glands, the thyroid, the lymph nodes, the peritoneum or retroperitoneal tissues (abdomen) and… the aorta. Noninfectious thoracic aortitis, periaortitis and idiopathic retroperitoneal fibrosis have all been linked to IgG4RD, according to their findings. Noninfectious aortitis refers to disorders that involve chronic inflammation within the aortic wall and importantly, can manifest from giant cell arteritis, rheumatoid arthritis, ankylosing spondylitis and Behçet's syndrome/disease. (Gee, what about those fibrin clots we saw in autopsy findings? Those who were 2,3,4,5x vaccinated? IgG4 mediated response leading to autoimmune issues?)
There is hallmark of IgG4RD called ‘storiform fibrosis’ which refers to an irregularly ‘whorled’ organization of collagen bundles.27 A collagen bundle looks like twisted licorice so imagine an irregularly whorled version of twisted licorice inside your body. If you’re in the lab looking for stuff going wrong from people who died in temporal proximity to getting these COVID injections, look for this.
Her second article:
“IgG4 class switching is associated with chronic exposure to antigen. This particular subclass of antibody can outcompete other antibody species, like IgG1, to subsequently block their effector mechanisms. One of these effector mechanisms imposed by IgG1 is tumor control (or suppression), mediated by antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC). These mechanisms are all ways to keep unwanted cells and material under control. (As in, IgG1 is the portion of our immunity that sweeps for cancer. If IgG4 suppresses IgG1, then tumor cells can grow out of control). In yesterdays post, we saw that IgG1 dropped with each additional vaccine.
So those three ways: the ADCC, ADCP and CDC - that aid in removal of unwanted cells are all nullified in the scenario where IgG4 is prevalent. Worse than that, since the subclass switch is literally the by-product of continuous antigen stimulation, then this is an immunological endorsement of a ‘win’ for IgG4 if we consider competition for binding sites. In effect, IgG4 outcompetes IgG1 and thus, the scales tip from tumor suppression, to tumor progression. All because of IgG4. Now I don’t want to scare everyone, but persistent re-injection of a messenger RNA that encodes a foreign, highly immunogenic protein, is NOT a good idea in this context. This is precisely continuous antigen stimulation by spike protein. Not only that, since we know that both the mRNA and the spike protein are long-lasting in the body, you mightn’t even have to re-inject yourself repeatedly qualify as undergoing continuous antigen stimulation. In fact, I would bet that this would be a given. Furthermore, I would bet that due to this continuous antigen stimulation, the IgG1:IgG4 subclass ratio is inverted in people who are persistently making spike, and that these people would be subject to cancer promotion, rather than suppression.
The answer train is chugging up the hill. The levels of increased IgG4 and decreased IgG3 explain why people are getting sick post vaccine, adults are spreading higher viral loads of illnesses to kids, people are having a hard time fighting off illness, and the development of fibrin clotting that we are seeing in autopsy findings. For those who doubted the vaccine was the cause, the evidence is quite compelling.
Jessica Rose is a great follow on Substack if you don’t already follow her!