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Isn’t depression due to an emotional response to reality bound to be medication resistant? If you lockdown, mask, coerce people to vaccinate, and give them a bad case of cognitive dissonance from all the lies and gaslighting, would this not lead to depression?

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100% agree.

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"Actually, we know for sure that's totally not it at all." -- The Science©

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Hello Jimmy. Here's a reasonable start re melatonin & serotonin affecting mood & depression. Root cause is we don't get enough direct sunlight into our eyes in the early morning time.

Melatonin is a hormone that your body produces when it is dark. It regulates your 24-hour internal clock and helps you fall asleep at night.

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Research suggests that melatonin may play a role in other brain and bodily functions, including mood and emotions. However, scientists still do not fully understand these effects.

Some people have reported that melatonin supplementation may exacerbate symptoms of depression by lowering their energy levels. However, there is limited evidence to substantiate these claims.

Other people have proposed that melatonin supplementation could improve depression symptoms in people living with major depressive disorder and other mental disorders. Scientific studies have so far shown mixed results, and more research is needed to see whether melatonin supplementation can be an effective complementary or alternative treatment for depression.

What Is Melatonin and What Is Its Role in the Body?

One of the main functions of melatonin is to regulate our biological rhythms. There are two different melatonin production pathways: pineal and extra-pineal.

Pineal Melatonin Synthesis

Pineal melatonin synthesis takes place in the pineal gland of the brain. Darkness at night triggers a pathway that begins in the retina of the eye, travels through our suprachiasmatic nucleus (which regulates circadian rhythms in the body), and ends in the pineal gland, where it prompts melatonin production.

This process typically begins about two hours after nightfall and is known as "dim light melatonin onset." Other external stimuli such as feeding schedules, rest-activity, and social cues also affect this pathway. Melatonin travels around the body from the pineal gland, spreading information about light and darkness and regulating daily functions.

Melatonin plays a vital role in regulating biological rhythms. Biological rhythms determine when certain bodily functions and behaviors occur and keep us 'in time' with the outside world.

However, the interactions between melatonin and our behavior are complex. While melatonin production may impact behavior - by making us want to sleep, for example - our behavior may also impact melatonin production by determining our light exposure, feeding behavior, and activity levels.

Extra-Pineal Melatonin Synthesis

Extra-pineal melatonin synthesis occurs in other body parts, including the skin, guts, and lungs. Extra-pineal melatonin only acts locally with no known effects on our biological rhythms.

How Might Melatonin Affect Depressive States?

Scientists have established that depressive states, including mood disorders, are associated with imbalances in hormones and neurochemicals, such as serotonin and dopamine. Recent research has explored whether misalignment of biological rhythms could contribute to these imbalances.

https://gia.miami/rehab-blog/can-melatonin-cause-depression/

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I have no doubt this plays a role. The question is, is melatonin supplementation also resisted as a depression treatment.

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Would be suppressed is a give. Mustn't get in the way of profit!

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