The effect of lipid nanoparticles on psych meds

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503827

This is a very interesting article.  Given my specialty, it takes on a particular interest.  Let’s dig in!

First, the now “admit” that mRNA vaccine technology, the lipid nanoparticles or LNP’s interfere with chemotherapy, anticonvulsants, and antimalarials.  Hmmm.  Why did we push cancer patients to get vaccinated?  Patients who take Clozapine for severe mental illness demonstrated elevated blood levels of clozapine after mRNA vaccination.  That is not good news either.

Anti-convulsants are often used as mood stabilizers in psychiatry.  Depakote, Lithium, and Lamictal.  So the fact that mRNA vaccines interfere with these medications is highly concerning.  Severe mentally ill patients are fragile, and if their medications are not properly taken and dosed, shit can go sideways real quick.  In 2021, we prioritized vaccinating this population.  But perhaps we were a little too quick to do so.

“Currently, there are very few studies on mRNA vaccine efficacy in patients with SPI in treatment with psychotropic drugs. However, increased breakthrough infections and limited vaccine responses were reported by a recent epidemiological study on veterans with SPI, highlighting possible drug-vaccine interaction (Nishimi et al., 2022). This study is in line with earlier data, showing that, in general, patients with SPI exhibit suboptimal vaccine effectiveness as do geriatric patients”.

WHOA STOP.  The entire generation of people that we created vaccines for, the elderly, are not benefitting from them and are in fact having negative consequences from the vaccine?  If you remember way way back when I was outing Pfizer, remember how their age group in “test trials” were no older than 55?  Now you know why.  The vaccine isn’t working in the elderly and the trials couldn’t show that or the entire narrative would be blown up.

The severe mentally ill population never needed the vaccine. SPI patients display an increased number of natural killer cell (NKC) that are unaffected by the psychotropic drugs, probably explaining the low prevalence of malignancy in the population as well as low rates of COVID-19 critical illness in this population.

“Interestingly, several psychotropic drugs, including aripiprazole, clozapine, and lithium, were demonstrated to alter ribosomal function and protein synthesis, highlighting possible interference with the vaccine mRNA.”

“A recent study found that upon entering the host nuclear compartment, Pfizer BioNTech mRNA could be retrotranscribed into DNA by the long interspersed nuclear element-1 (LINE-1), emphasizing vaccine-genome interactions.  Interestingly, upregulated LINE-1, a marker of SPI, can be lowered by psychotropic drugs (via DNA methylation), likely reducing, or averting the transcription of RNA to DNA.” What does this mean?  If you were taking certain psych drugs while getting vaccinated, you not only did not get the benefits of the vaccine (I say that tongue in cheek), but you also PROTECTED yourself by possibly preventing the uptake of the RNA into the conversion into the DNA in your body.  The vaccine was irrelevant in your body.

“Psychotropic drugs may lower the robustness of vaccine responses by direct mechanisms, interaction with LNPs, or indirectly by the anti-inflammatory and anti-immunogenic properties of these agents.  For example, the immunosuppressant properties of clozapine, haloperidol, risperidone, and antidepressant drugs are well-established, emphasizing likely interference with the vaccine-associated immunogenicity.  Indeed, biophysical studies show that antipsychotic drugs can insert themselves between the lipid molecules of plasma membrane, triggering anti-inflammatory responses that can impair vaccine efficacy.  Moreover, leukopenia and decreased immunoglobulins, well-established properties of psychotropic drugs, may directly lower vaccine-elicited neutralizing antibodies.”  Remember the FLCCC protocol discussing the use of Prozac and Luvox as part of the covid treatment protocol?  That is due to the immunosuppressant quality of SSRI’s.  They reduced inflammation and cytokine response.

Their conclusion? “We opine that more studies are needed to assess the interaction between the major classes of psychotropic drugs, including antipsychotics, antidepressants, and mood stabilizers with the mRNA therapeutics. As the polyethylene glycol (PEG) component of lipid nanoparticles (LNPs) increases the permeability of BBB for a short interval, we anticipate that LNPs will be rapidly adopted by neuropsychiatry as vehicles for drug transport and delivery to the select CNS networks. For this reason, it is important to develop a VAERS-like system for recording the interaction of psychotropic drugs with current and future mRNA therapeutics.  Treatment with psychotropic drugs may decrease the mRNA vaccine effectiveness by lowering inflammation/immunogenicity, inhibiting virus/LNP endocytosis, delaying ELS escape, or directly downregulating neutralizing antibodies.”