https://www.sciencedirect.com/science/article/pii/S0305417923001286
For those of you who have never seen Steven Johnson, or SJS as we abbreviate it in healthcare, it is a horrid reaction to have. Your body has an allergic like reaction where your epidermis blisters and peels. If greater than 30% of your body is affected, it is considered toxic epidermal necrolysis (TENs). It can be fatal. Thankfully, it is super rare. It is managed in the hospital on burn units due to the epidermis shedding and sloughing off the body. Skin grafting could be required. SJS or TENs can occur as a reaction to various antibiotics, antiepileptic medications, interactions of meds together, alcohol, etc. It is not a condition you want to get.
This article discusses the 7-fold increase in cases of SJS/TENs after the covid injection was deployed.
“In 2022, our institution saw a sharp rise in SJS/TEN presentations. As a state-wide burns unit and referral centre for SJS/TEN, our institution manages two to four cases per year, prior to COVID. In the first six months of 2022 however, we managed fourteen cases. Five of these cases had COVID in the preceding month. Three of the fourteen had a COVID vaccine in the preceding month. All fourteen cases received a COVID vaccine.”
One of the cases was particularly bad. The patient had more than 50% of their body affected, meaning it was a case of TENs:
Read through cases 2-8 and notice the trends between them. Many had covid, covid vaccines, and some other illness exacerbated that required another medication to be given to them, that they never had a negative reaction to before, and THIS time around they developed SJS/TENs.
They hypothesize 3 possibilities here:
Virus induced:
The SARS-COV-2 virus may directly bind to receptors that trigger a T cell mediated response and subsequently SJS/TEN. Many viruses have already been implicated in the development of SJS/TENS including herpes simplex virus, Epstein-Barr virus (EBV), cytomegalovirus and influenza [13]. Their viral proteins bind to the major histocompatibility (MHC) complex I on the antigen presenting cell triggering activation of cytotoxic T cells. This T cell mediated response may subsequently result in SJS/TEN. Five cases of COVID infection preceding SJS/TEN have been reported. The average time of onset from diagnosis was 3 weeks (range: 1 – 5 weeks). This is consistent with our cases with an average of 5 weeks,
Vaccine induced:
The vaccine may directly bind to receptors to trigger SJS/TEN. Many drugs, like viruses, have been implicated as triggers. It is recognised that drugs bind MHC class I to trigger a cytotoxic T cell response. A recent study found the ChAdOx1 nCoV-19 adenoviral vector vaccine induces T helper type 1 cells leading to clonal expansion of cytotoxic T cells and subsequent protection against severe COVID infection. This T cell response can also induce the granule mediated pathway of perforin, granulysin and granzyme B release to cause keratinocyte apoptosis seen in SJS/TEN. This response peaks between seven- and 28-days post vaccination [19]. This time peak is consistent with our cases. Eight case reports have been identified in the literature describing SJS/TEN post-COVID vaccine. Four of these cases were associated with mRNA vaccines, three with viral vector vaccines and one with whole virus vaccines. In our case series, two patients received a mRNA vaccine and one a viral vector in the preceding month to their presentation.
Threshold lowering:
The SARS-COV-2 virus or vaccine may lower the threshold for a drug to trigger SJS/TEN. We hypothesise that the virus or vaccine “primes” the immune system for a drug to cause SJS/TEN, which may not have done so without this “priming”. Infectious mononucleosis caused by EBV has this “priming” effect to induce a drug induced hypersensitivity (DiHS) reaction when an individual is exposed to penicillin. This DiHS manifests as a generalised rash. The large expansions of activated EBV-specific cytotoxic T cells and increased natural killer (NK) cell numbers are observed during the disease and EBV-specific T cells have been shown to cross-react with self-human leukocyte antigen alleles. The development of a drug rash during infectious mononucleosis may be due to cross reactivity between penicillins and the expansion of EBV- specific cytotoxic T cells already present prior to giving the drug.
I tend to lean towards the third option, threshold lowering. The vaccine is known to affect IgG with each subsequent vaccine. When the immune system capacity is reduced, the ability for other things to run amok increases. You take a patient who has had 3 covid vaccines, weakened T-cell response, they develop a sinus infection that will not resolve, they are given antibiotics, and due to poor immune response that drug (usually a penicillin based antibiotic) has the ability to cause serious problems, including SJS/TENs. At this point it would be hard to pinpoint covid virus as the primary cause, because it is difficult to find a recent covid infection patient that was not also vaccinated. We do not have access to the immune vulnerability of every single person. We do not draw those labs on a routine basis. Someone may be immunocompromised or vulnerable and we do not know. We add fuel to the fire with antibiotics and things can get scary.
Most of us know of at least one person who has had some type of respiratory infection recently whether it be sinus or chest illness, and have been through 1-3 rounds of antibiotics. I would believe they would be likely candidates of threshold lowering where their immune system couldn’t fight the original “summer cold”, it transitioned to a bacterial infection, and antibiotics did not even fight it off easily.
Makes ya wonder what fall/winter 2023-2024 is gonna look like. I suspect it won’t be pretty.
Thanks Jennifer. Horrible. The shots are a complete, deadly disaster. Not one "leader" will step up and stop the killings. Peace.
The photo of the skin sloughing off the back of this affected 60 year old is enough to scare you away from all vaccines and antibiotics. I will look more closely at what I put into my system going forward. Thank you.